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Clastogenic activity of integerrimine determined in mouse micronucleus assays
Maria Clara Gimmler-Luz; Bernardo Erdtmann
Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, Campos do Vale, Prédio 43323, Caixa Postal 15053, 91501-970, Porto Alegre, RS, Brasil, Fax: 5551 336 20 11. Send correspondence to M.C.G.-L.
ABSTRACT
The pyrrolizidine alkaloid integerrimine, obtained from Senecio brasiliensis, was tested by acute dosing at two concentrations (18.75 and 37.5 mg/kg), and at different times, to establish its ability to induce micronuclei in mouse erythrocytes. This alkaloid was able to increase the frequency of micronucleated polychromatic erythrocytes in both, bone marrow and peripheral blood erythrocytes.
Keywords: Clastogenic; integerrimine; mouse micronucleus.
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