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Cytogenetic study of 50 Brazilian patients with primary myelodysplastic syndrome
Teresa de Souza FernandezI; Maria Luiza M. SilvaI,II; Jamison M. de SouzaI,III; Daniel TabacII; Eliana AbdelhayI
ILaboratório de Biologia Molecular Maury Miranda, Instituto de Biofísica Carlos Chagas Filho, bloco G, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, 21949-900 Rio de Janeiro, RJ, Brasil. Send correspondence to E.A.
IIInstituto Nacional do Cāncer, Centro de Transplante de Medula Óssea, Praça Cruz Vermelha 23, 7° andar, Centro, Rio de Janeiro, RJ, Brasil.
III Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti, Rua Frei Caneca 8, Centro, Rio de Janeiro, RJ, Brasil.
ABSTRACT
In this work we analyzed cytogenetically 50 patients with primary myelodysplastic syndrome from several hospitals of Rio de Janeiro, Brazil. The frequency of cytogenetic abnormalities was 32%. Patients with refractory anemia, or refractory anemia with ringed sideroblasts, presented normal karyotypes or single abnormalities such as del(5q) or -Y, while patients with refractory anemia with an excess of blasts, refractory anemia with an excess of blasts in transformation or chronic myelomonocytic leukemia showed complex karyotypes and single abnormalities involving chromosomes 7 or 8, which are related to a bad prognosis and an elevated risk of evolution to acute myeloid leukemia.
Keywords: myelodysplastic syndrome; Cytogenetic; refractory anemia.
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