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Maternal inheritance of a 10/15 translocation in a female with a history of obstetric problems

Asha S. Multani^I; Uppala Radhakrishna^II; Frenny J. Sheth^III; Vinod C. Shah^III; Niloufer J. Chinoy^III; Sen Pathak^I

^IDepartment of Cell Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, Houston, TX 77030 USA. Tel.: (713) 792-2582; Fax: (713) 792-8747. Send correspondence to S.P.
^IIBiotechnology, National Dairy Development Board, Anand - 388001, India
^IIIDepartment of Zoology, Gujarat University, Ahmedabad - 380009, India

ABSTRACT

The karyotype 46,XX, -10, -15, t(10;15) (p15;q22) was observed in a lymphocyte culture of an Indian female with multiple abortions. Similar chromosome abnormalities were present in her mother, one brother, and three of her sisters. The presence of ascitis, cyanosis, and hepatic renal problems in her three daughters indicated possible effects of such chromosomal rearrangements.

Keywords: maternal inheritance; translocation; obstetric problems.

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