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Chromosome analysis of benign expansive processes in the adrenal cortex

Luis Alberto Espinoza; Cacilda Casartelli

Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brasil. Send correspondence to C.C.

ABSTRACT

Chromosome analysis was performed on an adrenocortical hyperplasia and an adenoma. The most frequently observed chromosome aberrations were monosomy of chromosomes 14 (hyperplasia), 5 and 8 (adenoma). The findings were compared to those described in adrenocortical tumors.

Keywords: chromosome analysis; adrenal cortex.

REFERENCES

Atkin, N.B. and Baker, M.C. (1991). Numerical chromosome changes in 165 malignant tumors. Evidence for a nonrandom distribution of normal chromosomes. Cancer Genet. Cytogenet. 52: 113-121.

Bishop, J.M. (1987). Molecular genetics of cancer. Science 235: 305-311.

Cotran, R.S., Kumar, V. and Robbins, S.L. (1989). The endocrine system. In: Robbins Pathologic Basis of Disease. 4th edn. (Rani, S., Kumar, V. and Robbins, S.L., eds.). WB Saunders Company, Philadelphia, pp. 1205-1276.

Della-Rosa, V.A. and Vianna-Morgante, A.M. (1994). Estudo citogenético de tumores da córtex da adrenal. Rev. Bras. Genet. 17 (Suppl.): A109.

Jaresch, S., Kornely, E., Kley, H.-K. and Schlaghecke, R. (1992). Adrenal incidentaloma and patients with homozygous or heterozygous congenital adrenal hyperplasia. J. Clin. Endocrinol. Metab. 74: 685-689.

Limon, J., Dal Cin, P., Kakati, S., Huben, R.P., Rau, U. and Sandberg, A.A. (1987a). Cytogenetic findings in a primary adrenocortical carcinoma. Cancer Genet. Cytogenetic. 26: 271-277.

Limon, J., Dal Cin, P., Gaeta, J. and Sandberg, A.A. (1987b). Translocation t(14;11)(q35;p13) in an adrenocortical carcinoma. Cancer Genet. Cytogenet. 28: 343-348.

Marks, J.L., Wyandt, H.E., Beazley, R.M., Milunsky, J.M., Sheahan, K. and Milunsky, A. (1992). Cytogenetic studies of an adrenal cortical carcinoma. Cancer Genet. Cytogenet. 61: 96-98.

Nowell, P.C. (1986). Mechanisms of tumor progression. Cancer Res. 46: 2203-2207.

Nowell, P.C. (1989). Chromosomal and molecular clues to tumor progression. Semin. Oncol. 16: 116-127. Stanbridge, E.J. (1990). Human tumor suppressor genes. Annu. Rev. Genet. 24: 615-657.

Studzinski, G.P. (1989). Oncogenes, growth and the cell cycle: an overview. Tissue Kinet. 22: 405-424.

Volpe, J.P.C. (1988). Genetic instability of cancer. Why a metastatic tumor is unstable and a benign tumor is stable. Cancer Genet. Cytogenet. 34: 125-134.

Weinberg, R.A. (1991). Tumor suppressor genes. Science 254: 1138-1146.

Wilson, J.D. and Foster, D.W. (1985). Normal and aberrant growth. In: Williams Textbook of Endocrinology (Undewood, L.E. and Van Wyk, S., eds.).. 7th edn. WB Saunders Company, Philadelphia, pp. 105-255.