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Integration of gene maps: mouse chromosome X

L.H. Wang; A. Collins; S. Lawrence; N.E. Morton

CRC Genetic Epidemiology Research Group, Human Genetics Centre, University of Southampton, Level G, Princess Anne Hospital, Southampton SO9 4HA, UK. Telephone: (0703) 79-6535, Fax: (0703) 79-4346. Send correspondence to N.E.M.

ABSTRACT

A linkage map was constructed from data in GBASE and integrated with physical and other data. The summary map contains 178 loci in 86 cM (164 Mb). Interference is at the level predicted by Carter and Falconer (J. Genet. 50: 307-323, 1951). Problems encountered in this exercise include data errors and omissions which an integrable location database could correct if it received some of the effort now devoted to subjective maps. The extent to which homologous sequences have been rearranged in mouse and man cannot be determined until steps are taken to make both maps more reliable. There has been remarkably little attention to problems of map integration that are common to all eucaryotes, and the need for a location database is as acute in the mouse as in man.

Keywords: gene maps; mouse; chromosome X.

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