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Urinary pepsinogen polymorphism in Jordanians classified according to blood group, cigarette smoking habits and region^*

Rima S. Alhajj^I; Amer Abu-Khalaf^I; Ghaleb M. Abuereish^II

^IFaculty of Medicine, University of Jordan
^IIDepartment of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan. Send correspondence to G.M.A.

ABSTRACT

The pattern of distribution of Urinary pepsinogen A (PGA) polymorphism phenotypes in 535 normal Jordanians, with respect to sex, age, ABO blood groups, cigarette smoking, and geographical distribution, was investigated. The phenotypes were determined with polyacrylamide gel electrophoresis. Seventeen discrete phenotypes, which differ with respect to the presence and relative intensity of the PGA groups (Pg5, Pg4 and Pg3), were identified. Each phenotype was consistent for each individual. A new PGA phenotype, BC > CC, was identified. The others differed in their frequencies from those of prevlously studied populations. No correlation between PGA phenotypes and age and sex of individuals was observed. Pg5 was more frequent in the AB blood group. Strong Pg5 and Pg4 were found more and less frequently, respectively, in cigarette smokers compared to nonsmokers. Furthermore, phenotypes with strong Pg5 were more frequently present in individuals of the eastern desert than in those of the mountainous region.

Keywords: urinary pepsinogen; polymorphism; Jordanians; blood group; cigarette; smoking habits.

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* Part of a thesis presented by R.S.A. to the University of Jordan, in partial fulfillment of the requirements for the Master's degree.