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Chromosomal changes in advanced primary gastric cancer

M. Angélica Alliende^I; Marcela Aranda^II

^IGenetic and Metabolic Diseases Unit, INTA, University of Chile, P.O. Box 13, Santiago 11, Chile
^IIDepartment of Chemistry and Biochemistry, Faculty of Science, University of Santiago of Chile, P.O. Box 307-2, Santiago, Chile. Send correspondence to M.A.

ABSTRACT

Successful cytogenetic analysis was performed in three advanced and one incipient case of gastric adenocarcinoma. Two of the advanced ones corresponded to undifferentiated adenocarcinoma, one of them with a chromosome number in the range of hyperdiploidy and the other in the hypodiploidy range. The third one was differentiated with an hypotriploid modal number. The incipient tumor (undifferentiated and tubular) presented a chromosome number in the range of diploidy.
Loss of chromosome 17 was detected in all three advanced gastric adenocarcinomas.
Structural alterations were observed at 1p in two tumors of differing histological types. A deletion was seen at 3p21 in one tumor and homogeneously staining regions (hsr) at 20p13 in another.

Keywords: chromosomal changes; gastric cancer.

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