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Cancer and cytogentics

Cacilda Casartelli

Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brasil

ABSTRACT

Some aspects of cancer cytogenetics are discussed here. Chromosomal rearrangements fall into three categories, based on the mechanism that promotes tumor growth: a) translocations, inversions and insertions; b) deletions and chromosome monosomies; c) amplifications. Oncogenes and tumor suppressor genes are involved in these alterations. Genomic imprinting, benign tumors and metastases are also discussed here.

Keywords: cancer; cytogentics.

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