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Preliminary report on the first Brazilian teratogen information service (SIAT)
Lavinia Schuler; Maria Teresa Sanseverino; Hernando Augusto Clavijo; Patricia Ashton-Prolla; Karen Boianowsky; Fernando Pecis; Fabricio Silva Costa; Érica Tatto; Vee Wong; Carmem Vinhas Santos; Roberto Giugliani
SIAT, Unidade dc Genética Médica, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035-003 Porto Alegre, RS, Brasil. Fax (051) 332-9661 or 3328324. Send correspondence to L.S.
ABSTRACT
The National System of information about Teratogenic Agents (SIAT) was set up in Porto Alegre, Southern Brazil, in 1990, with the purpose of providing doctors and the general public with rapid and updated information about the reproductive risks related to exposure to teratogenic agents. SIAT, which was the first service of this kind to operate in Latin America, is also an important source of data for prospective investigations about teratogenicity in humans. In this paper we report the preliminary experience of this service and its possible contributions. The introduction in 1992 of similar services in the two main Brazilian cities (Rio de Janeiro and São Paulo) and the operation of all three services within an integrated and coordinated national network enhance the potential of this service both at the health care and research levels.
Keywords: teratogen; information; agents.
REFERENCES
Castilla, E.E. (1990). Documento final da XXI Reunião Anual do ECLAMC. Editora da UFRJ, Rio de Janeiro, pp.9-11.
Castilla, E.E., Orioli, I.M. and Lopez-Camelo, J.S. (1985). On monitoring the multiply malformed infants: case finding, case recording, and data handling in a Latin American program. Am. J. Med. Genet. 22: 717-725.
Clavijo, H.A. (1991). Estudo sobre o consumo de medicamentos, álcool e fumo por gestantes na região de Porto Alegre, e avaliação do potencial teratogênico implicado. Master's Thesis, UFRGS, Porto Alegre.
Dicke, J.M. (1989). Teratology! principles and practice. Medical Clinics of North America 73:567-582.
Eléfant, E., Boyer, M., Boyer, P., Galliot, B. and Roux, C. (1992). Teratogenic agent information centre: fifteen years of counseling and pregnancy follow-up. Teratology 46: 35-44.
Kallen, B. (1987). Search for teratogenic risks with the aid of malformation registries. Teratology 35: 47-52.
Kalter, H. and Warkany, J. (1983). Congenital malformations: etiological factors and their role in prevention (first of two parts). N. Engl. J. Med. 308: 424-431.
Koren, G. (1990). Maternal Fetal Toxicology: a Clinician's Guide. Marcel Dekker, Inc., New York, pp. 351.
Lenz, W. (1992). A personal perspective on the thalidomide tragedy. Teratology 46: 417-418.
Lipson, A.H. (1992). Thalidomide retrospective: what did the clinician teratologist learn? Teratology 46: 411-413.
Lindhout, D. and Meinardi, H. (1984). Spina bifida and in utero exposure to valproate. Lancet 2: 396.
Martinez-Frias, M.L., Salvador, J. and Rodriguez-Pinilla, E. (1989). Valproate and spina bifida. Lancet 1: 1392-1393.
Matroiacovo, P., Bertollini, R., Morandini, S. and Segni, G. (1983). Maternal epilepsy, valproate exposure and birth defects. Lancet 2: 1499.
Robert, E. (1992). Handling surveillance types of data on birth defects and exposures during pregnancy. Reproductive Toxicology 6: 205-209.
Robert, E. and Guibaud, P. (1982). Maternal valproic acid and congenital neural tube defects. Lancet 2: 937.
Robert, E., Lofkvist, E. and Mauguiere, F. (1984). Valproate and spina bifida. Lancet 2: 1392.
Schuler, L., Ashton, P.W. and Sanseverino, T. (1992). Teratogenicity of Misoprostol. Lancet 339: 437.
Sheppard, T.H. (1992). Catalog of teratogenic agents. 7th edn. The Johns Hopkins University Press, Baltimore, pp. xxi-xxiii.