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Lack of association between paracoccidioidomycosis and HLA histocompatibility antigens. Revista Brasileira de Genetica

Jeane Eliete Laguila Visentainer^I; Luíza Tamie Tsuneto^I; Ricardo Alberto Moliterno^I; Flávio de Queiroz Telles Filho^II

^IDepartamento de Análises Clínicas, Universidade Estadual de Maringá, 87020-900 Maringá, PR, Brasil. Send correspondence to J.E.L.V.
^IIHospital das Clínicas de Curitiba, Curitiba, PR, Brasil

ABSTRACT

A study on association between HLA and disease was carried out. Forty caucasian patients with clinical and laboratorial diagnosis of Paracoccidioidomycosis (PCM) and eighty healthy caucasian individuals, used as controls, were typed for the antigens HLA-A, -B, -Cw, -DR and -DQ.
There was a positive association of antigens HLA-A1 (p = 0.050), -A3 (p = 0.014), -B8 (p - 0.014), -Cw7 (p = 0.020), -DQw2 (p = 0.014) and -DQw3 (p = 0.019) in patients, and a negative association of antigens HLA- Cw3 (p=0.032), -DR 1 (p = 0.019) and -DQw1 (p = 0.003) in the same group (compared to the controls, and without correction for the number of antigens tested (50)). The results suggest a fragile association of these HLA antigens with the disease, since other factors may also influence the genetic susceptibility to PCM. No significant association was demonstrated in this study when the value of P was corrected according to Svejgaard and Ryder (HLA and Disease, J. Dausset and A. Svejgaard, eds., 1977).

Keywords: lack; paracoccidioidomycosis; Histocompatibility; antigens.

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