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Influence of the rapid acetylator phenotype on the emergence of DDS resistant Mycobacterium leprae

Holmes Campanelli Costa^I; Diltor Vladimir Araujo Opromolla^I; Marcos Virmond^I; Bernardo Beiguelman^II

^IInstituto Lauro de Souza Lima, Caixa Postal 62, 17100 Bauru, SP, Brasil
^IIDepartamento de Genética Médica, Faculdade de Ciencias Médicas, UNICAMP, Caixa Postal 6111, 13081-970 Campinas, SP, Brasil. Send correspondence to B.B.

ABSTRACT

Twenty one lepromatous cases with suspected diaminodiphenyl sulfone (DDS) resistance had their isoniazid acetylator phenotype determined. The resistance of Mycobacterium leprae to this sulfone was investigated by means of foot pad tests in BALB/c mice. Results indicate that the emergence of complete resistance to DDS in M. leprae is more probable in rapid than in slow acetylators. It appears that rapid acetylators require higher doses of DDS than slow acetylators since the bacillary concentration in the lesions of the patients with DDS sensitive M. leprae was more than 17 times higher among rapid than among slow acetylators.

Keywords: cetylator; phenotype; DDS resistant; Mycobacterium leprae.

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