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Sister chromatid chromatid exchanges in heterozygote b thalassaemic patients with normal folate levels

Ana Elizabete Silva^I; Antônio José Manzato^II; Marileila Varella-Garcia^I

^IDepartamento de Biologia
^IIDepartamento de Ciências de Computação e Estatística, Instituto de Biociências, Letras e Ciências Exatas - UNESP, 15054-000 São José do Rio Preto, SP, Brasil. Send correspondence to A.E.S.

ABSTRACT

Lymphocytes from b thalassaemia heterozygote patients, with normal levels of plasma folic acid cultured for 72 h in a folate rich medium, were not found to contain increased rates of sister chromatid exchanges (SCE). A wide intra and interindividual variability was found in both thalassaemic and control groups and methodological and biological factors, such as types of peripheral lymphocytes, sex, age, and smoking, alcohol and coffee drinking, as well as dietary habits, are possibly responsible for these variations.

Keywords: Sister chromatid exchanges; Thalassaemic patients.

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