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del(4)(p14) + 4ace, t(4;15) (p14;pter), new characteristic chromosome anomalies of acute lymphoblastic leukemia?

M.I.M. Amorim^I; J.A.R. Lemos^I; L.M.C. Maradei-Pereira^II; I.R. Cabral^I

^IDepartamento de Biologia, Centro de Ciências Biológicas, Universidade Federal do Pará, 66059 Belém, PA, Brasil. Send correspondence to M.I.M.A.
^IICentro de Hemoterapia e Hematologia do Pará, 66010 Belém, PA, Brasil

ABSTRACT

In this work we report a patient with acute Lymphoblastic Leukemia (ALL) whose bone marrow presented chromosome anomalies cells when submitted to cytogenetic examination, which have been previously reported for this condition (del(6) (q23); t(9;22) (q34;q11)) as well as others as yet unreported for ALL (del(4) (p14) + 4ace and t(4;15) (p14;pter)). We discuss the hypothesis that these anomalies influence the origin of the malignancy, patient response to treatment and prognosis, possibly through oncogene activation.

Keywords: Chromosome anomalies; Lymphoblastic leukemia.

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