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Genetic aspects of Schistosoma mansoni infection severity

Tania de A. Weimer^I; José Tavares-Neto^II; Maria H.L.P. Franco^I; Mara H. Hutz^I; Francisco M. Salzano^I; Rumi R. Kubo^I; Russel T.D. Rosa^I; João R. Friedrisch^I; Aluisio Prata^II

^IDepartamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Caixa Postal 15053, 91501 Porto Alegre, RS, Brasil. Send correspondence to T.A.W.
^IIFaculdade de Medicina do Triângulo Mineiro, Praça Tomaz Ulhoa, 706, Caixa Postal 118, 38025 Uberaba, MG, Brasil

ABSTRACT

Genetic variability of 13 proteins have been investigated in a sample of 61 subjects with hepatosplenic (H) and 61 with intestinal (I) schistosomiasis, living in an endemic area (Catolandia, State of Bahia). Only one significant difference was found in the genotypic distributions between H and I patients. GLO^*1/GLO^*1 homozygotes have a relative incidence of hepatosplenic schistosomiasis four times and GLO^*1/GLO^*2 heterozygotes three times higher than GLO^*2/GLO*2 homozygotes.

Keywords: Schistosoma mansoni.

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