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Chromosome studies in males affected by duchenne or becker muscular dystrophy

Denise A.S. Batista^I; Angela M. Vianna-Morgante^II; Mayana Zatz^II

^IDepartamento de Genética, Instituto de Biociências, UNESP, Rubião Júnior, 18610 Botucatu, SP, Brasil. Send correspondence to D.A.S.B.
^IIDepartamento de Biologia, Instituto de Biociências, USP, Caixa Postal 11461, 05499 São Paulo, SP, Brasil

ABSTRACT

We studied cytogenetically 48 male patients with Duchenne or Becker muscular dystrophy. All of them showed normal X chromosomes. Fragility of Xp21 was investigated in 1400 G-banded chromosomes of 28 patients and only one break was observed at this band (0.07%). This low frequency of breakage excludes Xp21 as a fragile site in these patients.

Keywords: Duchenne; Becker; Muscular dystrophy.

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