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Frequency and glomerular or post-glomerular origin of hematuria in Brazilian patients with sickle cell syndromes

 

 

Marilda de Souza Gonçalves; Antonio Sérgio Ramalho

Departamento de Genética Médica, Faculdade de Ciências Médicas, UNICAMP, Caixa Postal 6111,13081 Campinas, SP, Brasil. Send correspondence to A.S.R.

 

 

ABSTRACT

The occurrence of hematuria was investigated prospectively and retrospectively in a sample of 50 adult patients with sickle cell anemia, hemoglobin SC disease or S/b-thalassemia. The glomerular or post-glomerular origin of hematuria was determined by the investigation of erythrocyte dysmorphism.
During a follow-up period of one year, one or more episodes of hematuria occurred in 11/50 of the patients and the glomerular origin of this manifestation was recognized in 2/10 of all cases. Patients with glomerular damage presented continuous hematuria, whereas patients with post-glomerular damage presented episodic hematuria. The frequency of hematuria did not differ significantly between SS and SC patients or between patients with sickle cell disease and a general control sample from the same hospital. Previous episodes of hematuria confirmed by laboratory tests occurred in 18/50 cases, although t heyvaried with follow-up time.

Keywords: Glomerular; Post-glomerular; Hematuria; Sickle cell syndromes.

 

 

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