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Cytogenetic study of benign mesenchymal neoplasisas

 

 

C. CasartelliI; M.A.M. RuzzeneI; S.R. RogattoII; J. Barbieri NetoIII; P.M.P. PhilbertIV

IDepartamento de Genética, Faculdade de Medicina, USP, 14049 Ribeirão Preto, SP, Brasil. Send correspondence to C.C.
IIDepartamento de Biologia Geral, Universidade Estadual de Londrina, 86051 Londrina, PR, Brasil
IIIDepartamento de Patologia, Faculdade de Medicina, USP, 14049 Ribeirão Preto, SP, Brasil
IVDepartamento de Ginecologia, Faculdade de Medicina, USP, 14049 Ribeirão Preto, SP, Brasil

 

 

ABSTRACT

Three human uterine Heiomyomas were cultured and analyzed cytogenetically. Although the modal chromosome number was in the diploid range, all the neoplasias had hyperdiploidy. One of the cases had 27% of the cells in the hypertriploid-hypertetraploid range.
The most frequent numerical alterations were monosomies involving chromosomes 20 (in all three of the cases) and 2, 17, 18 (2 cases each), and one case had polysomies of all chromosomes (ranging from trisomy to pentasomy). One case had a large ring chromosome similar to chromosome 1, and a marker with the rearrangement: t(2;12) (2qter—> 2q13::12q14-15 —> 12pter).The significance of cytogenetic alterations in benign tumors has yet to be determined.

Keywords: Cytogenetic; Mesenchymal neoplasias.

 

 

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