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Phenotypes of the CHE2 locus of serum cholinesterase and adult weight in a sample from blumenau, Santa Catarina, Brazil

 

 

Eleidi A. Chautard-Freire-MaiaI; Norma Stueber-OdebrechtII; C. JungetII; M.A. Canever de LourençoI; S.L. Primo-ParmoI; J.M.X. CarrenhoI

IDepartamento de Genética, Universidade Federal do Paraná, Caixa Postal 19071, 81504 Curitiba, PR, Brasil. Send correspondence to E.A.C.-F.-M.
IIDepartamento de Ciências Básicas e da Educação, Universidade Regional de Blumenau, Caixa Postal 7-E, 89100 Blumenau, SC, Brasil
IIICentro Hemoterápico de Blumenau, 89100 Blumenau, SC, Brasil

 

 


ABSTRACT

A sample of 689 blood donors was analysed with the aim of searching for an influence of the CHE2 locus of serum cholinesterase on adult weight. A frequency of 6.82% of the CHE2 C5 + phenotype was observed. The data showed that the distribution of weight is positively correlated with that of serum cholinesterase activity in one phenotype (CHE2 C5-) and independent of it in the other (CHE2 C5+).

Keywords: CHE2 locus; Cholinesterase; Brazil.


 

 

REFERENCES

Ashton, G.C. and Simpson, N.E. (1966). C5 types of serum cholinesterase in a Brazilian population. Am. J. Hum. Genet. 18: 438-447.

Berry, W.T.C., Cowin, P.J. and Davies, D.R. (1954). A relationship between body fat and plasma pseudo-cholinesterase. Brit. J. Nutr. 8: 79-82.

Chautard-Freire-Maia, E.A., Lourenço, M.A.C. and Jugend, R.M. (1984). Phenotype frequencies of the CHEZ locus of serum cholinesterase in a sample collected in Curitiba. Rev. Brasil. Genet. 7: 709-715.

Chu, M.I., Fontaine, P., Kutty, K.M., Murphy, D. and Redheendran, R. (1978). Cholinesterase in serum and low density lipoprotein of hyperlipidemic patients. Clin. Chim. Acta 85: 55-59.

Cucuianu, M., Opincaru, A. and Tapalagã, D. (1978). Similar behaviour of lecithin:cholesterol acyltransferase and pseudocholinesterase in liver disease and hyperlipoproteinemia. Clin. Chim. Acta 85: 73-79.

Cucuianu, M., Popescu, T.A. and Haragus, St. (1968). Pseudocholinesterase in obese and hyperlipemic subjects. Clin. Chim. Acta 22: 151-155.

Dubbs, C.A. (1966). Ultrasonic effects on isoenzymes. Clin. Chem. 12: 181-186.

Hutchinson, A.O., McCance, R.A. and Widdowson, E.M. (1951). Serum cholinesterases. In: Studies of Undernutrition, Wuppertal, 1946-1949. Spec. Rep. Ser. Med. Res. Coun. (Lond.) 275: 216-225.

Kalow, W. and Gunn, D.R. (1959). Some statistical data on atypical cholinesterase of human serum. Ann. Hum. Genet. 23: 239-250.

Kutty, K.M. and Acharya, C.D. (1972). Serum cholinesterase and lipoproteins: a possible relationship. Scand. J. Clin. Lab. Invest. (Suppl. 126) 29, Abstract, 3.28.

Kutty, K.M., Jacob, J.C., Hutton, Ci., Davis, P.J. and Peterson, S.C. (1975). Serum beta-lipoproteins: studies in a patient and in guinea pigs after the ingestion of organophosphorus compounds. Clin. Biochem. 8: 379-383.

Kutty, K.M., Redheendran, R and Murphy, D. (1977). Serum cholinesterase: function in lipoprotein metabolism. Experientia 33: 420-421.

Kutty, K.M., Rowden, G. and Cox, A.R. (1973). Interrelationship between serum B-lipoprotein and cholinesterase. Canad. J. Biochem. 51: 883-887.

Lawrence, S.H. and Melnick, Pi. (1961). Enzymatic activity related to human serum beta-lipoprotein: histochemical, imuno-electrophoretic and quantitative studies. Proc. Soc. Exp. Biol. Med. 107: 9881001.

Morrow, A.C. and Motulsky, A.G. (1968). Rapid screening method for the common atypical pseudo-cholinesterase variant. J. Lab. & Clin. Med. 71: 350-356.

Mourant, A.E., Kopec, A.C. and Domaniewska-Sobczak, K. (1976). The Distribution of the Human Blood Groups and other Polymorphisms. 2nd ed. Oxford University Press, London, pp. 705-709.

Robinson, A.R, Robson, M., Harrison, A.P. and Zuelzer, W.W. (1957). A new technique for differentiation of hemoglobin. J. Lab. Clin. Med. 50: 745-752.

Ryhänen, RJ.J., Jauhianen, MS., Laitinen, M.V. and Puhakainen, E.V. (1982). The relationships between human serum pseudocholinesterase, lipoproteins, and apolipoproteins (APOHDL). Biochem. Med. 28: 241-245.

Simpson, N.E. (1966). Factors influencing cholinesterase activity in a Brazilian population. Am. J. Hum. Genet. 18: 243-252.

Stueber-Odebrecht, N., Chautard-Freire-Maia, E.A., Primo-Parmo, S.L. and Carrenho, J.M.X. (1985). Studies on the CHE1 locus of serum cholinesterase and surnames in a sample from Santa Catarina (Southern Brazil). Rev. Brasil. Genet. 8: 535-543.

Van Ros, G. and Vervoort, T. (1973). Frequencies of the "atypical" and C5 variants of serum cholinesterase in Zairians and Belgians. Detection of the C5 variant by agar gel electrophoresis with an acid buffer. Ann. Soc. Belge Méd. Trop. 53: 633-644.