Full text in pdf format

Blood groups in a large sample from the city of São Paulo (Brazil): Allele and Haplotype frequencies for MMSs, Kell-cellano, Rh and ABO systems

Nativa N. Salaru^I; Paulo A. Otto^II

^IDepartamento de Medicina Legal, Faculdade de Medicina, USP, Laboratório de Investigação Médica LIM-40, São Paulo, SP, Brasil
^IIDepartamento de Biologia, Instituto de Biociências, Universidade de São Paulo, Caixa Postal 11.461, 05499 São Paulo, SP, Brasil. Send correspondence to P.A.O.

ABSTRACT

In the present paper we estimate the allele and, for the case of complex loci, haplotype frequencies for the following blood group systems in a large population sample consisting of unrelated individuals: MNSs, Kell-Cellano, Rh (5-6 sera) and ABO. The individuals of our sample, studied at the Departamento de Medicina Legal da Faculdade de Medicina da Universidade de São Paulo, were assembled into four major racial groups: whites, blacks, mongoloids and mulattoes. Besides comparing allele and phenotype frequencies among the racial subsamples, we also calculated the degree of racial admixture in the subsample of individuals classified as mulattoes. We also present a simplified method for estimating the frequencies of A₁ and A₂ alleles among A and AB individuals tested with anti-A and anti-B sera and anti-A₁ lectin.

Keywords: Blood groups; Brazil; MMSs; Kell-cellano; Rh.

REFERENCES

Beiguelman, B. (1972). Dinâmica dos genes nas populações e nas famílias, Edart, Sio Paulo, 2nd Edition.

Beiguelman, B. (1977). Dinâmica dos genes nas famílias e nas populações, Edart/EDUSP, Säo Paulo.

Beiguelman, B. (1983). Farmacogenética e sistemas sangüíneos eritrocitários, Guanabara Koogan, Rio de Janeiro.

Cavalli-Sforza, L.L. and Bodmer, W.F. (1971). The genetics of human populations, W.H. Freeman, San Francisco.

Elandt-Johnson, R.C. (1971). Probability models and statistical methods in genetics, John Wiley & Sons, New York.

Fisher, R.A. (1946a). The fitting of gene frequencies to data on Rhesus reactions. Ann. Eug. 13: 150-155.

Fisher, R.A. (1946b). Note on the calculation of the frequencies of Rh allelomorphs. Ann. Eug. 13: 223-224.

Mourant, A.E., Kopec, A.C. and Domaniewska-Sobczak, K. (1976). The distribution of human blood groups and other polymorphisms, Oxford University Press, London, 2nd Edition.

Salzano, F.M. (1971). Genetic polymorphisms in Brazilian populations. In: The ongoing evolution of Latin American populations (Salzano, F.M. ed.), Charles C Thomas, Springfield.

Stevens, W.L. (1938). Estimation of blood-groups gene frequencies. Ann. Eug. 8: 362-375.

Stevens, W.L. (1950). Statistical analysis of the A-B-O blood groups. Hum. Biol. 22: 191-217.