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Evidence for non-mutagenicity of epichlorohyrin in Drosophila melanogaster

A. Velázquez; N. Xamena; A. Creus; R. Marcos

Unitat de Genética. Departament de Genética i Microbiologia, Universitat Autônoma de Barcelona, 08193 Bellaterra (Spain). Send correspondence to R.M.

ABSTRACT

The possible mutagenic effect of epichlorohydrin (ECH) on male germ cells of Drosophila melanogaster was studied.
Feeding of adults and injection with ECH were unable to induce a significant increase in the frequency of sex-linked recessive lethal mutations in an insecticide-resistant strain. Adult injection in a sensitive strain was also ineffective.
Moreover, negative results were obtained when ECH was tested for its ability to induce sex-chromosome loss and non-disjunction.

Keywords: Epichlorohydrin; Drosophila melanogaster.

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