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Diabetes mellitus and some genetic markers

C.A.A. Barbosa^I; L.M.C. Koberle^III; C.V. Caiado^I; J.C. Pedrazzani^II; E.M. Vignali^II; Y. Lescura^II

^IDepartamento de Ciências da Saúde, Universidade Federal de São Carlos, 13560 São Carlos, SP, Brasil. Send correspondence to C.A.A.B.
^IIDepartamento de Enfermagem, Universidade Federal de São Carlos, 13560 São Carlos, SP, Brasil
^IIIClínica São Lucas, Rua 15 de Novembro, 1688, 13560 São Carlos, SP, Brasil

ABSTRACT

The phenotypic distributions of some genetic markers [GLO, ESD, Hp, PGM, ABO, Rh] ' were studied in a sample of diabetes patients and in their normal relatives. A statistically significant association between the haptoglobin system and type II diabetes was detected. The relative risk of having type II diabetes was about 2.5 higher for Hp 2-2 individuals. However, since 12 tests of heterogeneity between groups were performed, it was expected that about one of them would be significant by chance alone. Therefore, the observed Hp association could be a result of a type I statistical error

Keywords: diabetes; mellitus; genetic; markers.

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