Full text in pdf format

ABH antigens in north indians^*

Suraksha Agarwal

Department of Medicine, K.G.'s Medical College, Lucknow 226 003, India. Send correspondence to the author's present address: Department of Genetics and Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Post Box No. 375 GPO, Lucknow-Raebareli Road, Lucknow 226 001, India

ABSTRACT

The gene frequencies of the ABH secretor character and the average quantity of such substances in saliva were estimated in 166 male individuals of North Indian origin. These subjects were characterized as secretors, non secretors and aberrant secretors by using a quantitative method of agglutination inhibition. On this basis, 64.45% were defined as secretors, 21.08% as non secretors and 14.45% as aberrant secretors. The gene frequencies calculated were se = .4592 and Se = .5408.
Quantitative assessment of the blood group substances in saliva shows that 50% of group
A individuals are strong H secretors, however, most of them are also strong A secretors. Most of group. B individuals were weak H secretors and strong B secretors. Salivary antigen A was secreted more strongly in group A then in group AB, while substance B was secreted almost equally in both
B and AB blood groups. Aberrant secretion index (ASI) was calculated and compared with the other available published literature on the Indian populations.

Keywords: ABH; antigens; indians.

REFERENCES

Bhalla, V. and Bhasin, S. (1976). A study of blood group antigens in saliva. Indian J. Med. Res. 64: 1245-1249.

Bhatia, H.M. and Randeria, K.J. (1970). Studies on blood group antigens in saliva: Incidence and type of aberrant secretors. Indian J. Med. Res. 58: 194-201.

Clarke, C.A., McConnell, R.B. and Shepperd, P.M. (1960). A genetical study of the variations in ABH secretions. Ann. Hum. Genet. 24: 295-307.

Dunsford, I. and Bowley, C.C. (1967). Techniques in Blood Grouping. Vol. II. Oliver and Boyd, Edinburgh and London.

Holborow, E.J., Brown, P.C., Glynn, L.E., Hawes, M.D., Gresham, G.A., Brien, T.F. and Commbs, R.R.A. (1960). The distribution of the blood group A antigens in human tissues. Br. J. Exp. Pathol. 41: 430-437.

McNeil, C., Trentelman, E.F., Kreutzer, V.O. and Fullmer, C.D. (1957). Aberrant secretion of salivary A, B, and H group substances in human beings. Am. J. Clin. Pathol. 28: 145-151.

Randeria, K.J. and Bhatia, H.M. (1971). Quantitative inhibition studies on the ABH and Lewis antigens in saliva. Indian J. Med. Res. 59: 1737-1753.

Roy, M.N. and Chatterjee, J.B. (1962). Aberrant secretion of blood group substances in human saliva. Ind. J. Med. Res. 50: 191-194.

Schiff, F. and Sasaki, H. (1932). Der Ausscheidungstypus, ein auf Serologischem Wege nachweisbares Mandelndes Merkmal. KIM. Wochenschr. 11: 1426-1429.

Szulman, A.E. (1962). The histological distribution of the blood group substances in man is disclosed by immunofluorescence. II. The H antigen in its relation to A and B antigens. J. Exp. Med. 115: 977-996.

Szulman, A.E. (1966). Chemistry, distribution and function of blood group substances. Annu. Rev. Med. 17: 307-322.

* Research carried out at ICMR Centre for Advanced Research in Genetics.