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Chromosome analysis of 52 spontaneous abortuses in Brazil

Denise Pontes Cavalcanti^I; Iris Ferrari^II; Walter Pinto Jr.^I

^IDepartamento de Genética Médica, Faculdade de Ciências Médicas, UNICAMP, Caixa Postal 1170, 13081 Campinas, SP, Brasil. Send correspondence to D.P.C.
^IIDepartamento de Genética e Matemática Aplicada à Biologia, Faculdade de Medicina de Ribeirão Preto, USP, 14049 Ribeirão Prato, SP, Brasil

ABSTRACT

Chromosome analysis of 52 spontaneous abortuses from first-and second-trimester pregnancies showed that 56.7% of them had an abnormal chromosome constitution. Autosomic trisomies were the most common finding among the chromosomally abnormal abortuses. Evaluation of the origin of the 46,XX normal karyotypes through chromosome polymorphisms showed a high level of maternal cell contamination in the cultured material. On the basis of the present data and of a review of other reports, we conclude that a 46,XX karyotype in a first-trimester abortus can only be considered real after a comparative study of chromosomal polymorphisms in the abortuses and their respective parents.

Keywords: chromosome; spontaneous; abortuses; Brazil.

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