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Down syndrome in São Paulo state, Brazil, from 1960 to 1980

Sandra Maria Coscia; Nilda Martello

Departamento de Genética, Instituto Básico de Biologia Médica e Agrícola, UNESP, 18610 Botucatu, SP, Brasil. Send correspondence to N.M.

ABSTRACT

Using a methodology developed by Martello et aL, 1984 (Rev. Brasil. Genet. VII: 157- 173) a comparative analysis was made of the estimated incidence of Down syndrome for São Paulo State (Brazil) in the years 1960, 1965, 1970, 1975 and 1980. These incidences have continuously decreased as a result of the decreased contribution by mothers over 35 years of age to the total number of affected. The demographic reasons for these findings are discussed, and comparisons of our data with other estimates are made.

Keywords: down syndrome; São Paulo.

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