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Dipbenylhydantoin effects in balb c mouse bone marrow cells: cytogenetic aspects

Alice Reis de Oliveira; Lyria Mori; Gláucia M. Machado-Santelli

Fundação "Centro de Pesquisa de Oncologia", Rua Oscar Freire, 2396, 05409 São Paulo, SP, Brasil. Send correspondence to A.R.O.

ABSTRACT

The effect of the anticonvulsant díphenylhydantoin on chromosomes of Balb C mouse bone marrow cells was evaluated. An increase in the frequency of aneuploid cells was observed when a teratogenic schedule of treatment was used. The therapeutic levels did not induce the same cytogenetic abnormality. No clastogenic effect resulted from either treatment.

Keywords: dipbenylhydantoin; balb c; mouse; bone; marrow; cells; cytogenetic.

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