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Action of the pyrrolizidine alkaloid integerrimine in inducing meiotic chromosome aberrations in male mice

Maria Clara Gimmler-Luz; Edmundo Kanan Marques ; Rhona Carol Johnston

Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Caixa Postal 1953, 90001 Porto Alegre, RS, Brasil. Send correspondence to M.C.G.-L.

ABSTRACT

Male C₃H/HeJ and C_S7BL/6 mice were exposed to doses of 6.25, 12.50, 25 and 50 mg/kg body weight of the pyrrolizidine alkaloid integerrimine during phase S (pre-leptotene) of meiosis. No effect was detected on structural or numerical chromosomes aberrations investigated during diakinesis/metaphase I.

Keywords: pyrrolizidine; alkaloid; integerrimine; meiotic; chromosome; aberrations; male; mice.

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